Developed by HDA’s EDI 850 Task Force, this electronic data interchange (EDI) transaction set explains the application of the Accredited Standards Committee (ASC) X12 standards to the Purchase Order (PO) transaction set for use in healthcare distribution. The guideline provides updated Drug Supply Chain Security Act (DSCSA)-compliant recommendations for wholesale distributors in coding EDI 850s and generating subsequent EPCIS transaction data related to standard wholesale distributor replenishment orders, as well as dropship orders. New revisions in this edition include but are not limited to: Dispenser PO number in a REF segment immediately following the wholesaler PO in the BEG segment; numerous notes guiding the formation of the DSCSA EPCIS data for the dropship transaction resulting from a dropship PO; addition of a sold-to party to designate either a 340b covered entity or dispenser corporate owner of the product; state license number of the dispenser involved in the transaction; and revised business case examples showcasing the afore mentioned new features.